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“The American Society of Anesthesiologists recently released a consensus-based guideline recommending holding [glucagon-like peptide-1 receptor agonists (GLP-1RAs)] before an endoscopic or surgical procedure to decrease the risk of aspiration,” Yee Hui Yeo, MD, a resident in the Karsh Division of Gastroenterology and Hepatology at Cedars-Sinai Medical Center in Los Angeles, and colleagues wrote in Gastroenterology

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some report increased energy from higher metabolism, others report fatigue from calorie restriction When Side Effects Improve Most side effects follow a predictable pattern tied to dose escalation: Peak: First 1-2 weeks at a new dose or initial start Improvement: Week 3-4 as body adapts (receptor desensitization, GI adaptation) Stabilization: By week 6+, most patients report minimal or no side effects at the same dose Dose increase: Symptoms may temporarily return (usually milder than initial onset) For detailed management strategies and what to watch for, see our complete retatrutide side effects guide